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In absolute terms, under high immune escape, vaccinating only high-risk groups averted 76,000 hospitalizations (95% CI, 34,000-118,000) and 7,000 deaths (95% CI, 3,000-11,000) versus no recommendation

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This kind of compounds shows a high specificity for IRAP against APN (Compound 8 IC 50 = 5.8 M) and according to docking studies, the inhibitor acts in a binding pocket close to the GAMEN loop without interacting with the zing atom, leading to uncompetitive inhibition, confirmed later on by kinetic studies