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Synthesis of NO in endothelial cells Endothelial cells synthesize NO through the metabolic conversion of L-arginine mediated by the eNOS [65]

Clin Biochem 42:949957 Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J (2002) Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders

Meanwhile, regular activation of HIF-2 activates a pro-inflammatory response that causes intestinal damage (Shah, 2016)

314 ISRIB restores eIF2B function and enhances gemcitabine-induced pancreatic cancer cell death

However, currently available drugs fall short in some cases, prompting clinicians to search for therapeutic alternatives [9]