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However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease

The C31S SVD deconvoluted spectra reveal an initial phase in which flavin reduction and long-wavelength charge transfer (absorption centering around 660 nm) accumulate with a rate constant of 840 40 s 1

Lead disposition and kinetic model for lead bioaccumulation

Enhanced proliferation of released CD8 + T cells was observed for all tested inhibitors, indicating that this effect was neither drug specific nor restricted to inhibition of a particular phase of the cell cycle