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These experiments showed that NAPQI-induced cell death was reduced by increased GPx3 expression and was enhanced by decreased GPx3 expression, suggesting a crucial role for intracellular GPx in preventing the oxidative stress induced by NAPQI

S15), including C

Notably, the ROS-induced NFkB response is multi-faceted since it can activate the expression of both antioxidant proteins, including MnSOD, Cu/ZnSOD, CAT 52 , 54 - 57