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Therefore, targeting TFEB may be a promising strategy for the treatment of AD

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Relevant pharmacokinetic parameters for dihexa as determined after IV dosing are summarized in Table 9

sEH has specifically been shown to be the main enzyme that degrades epoxy-PUFAs (Zeldin et al., 1995), but mEH hydrolyzes these substrates with high enantiomeric selectivity (Zeldin et al., 1993