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They act indirectly by enzymatically removing reactive oxygen species and binding metals that catalyse the formation of free radicals (Ayoka et al

Among the ergot-derived dopamine agonists, bromocriptine, marketed as Parlodel, is administered orally

Recent investigations into key regulatory pathways, including mechanistic target of rapamycin, sirtuins, and adenosine monophosphate-activated protein kinase, have considerably deepened our understanding of metabolic dysregulation and opened new avenues for therapeutic innovation

These include (I) hemoglobinopathies, such as SCD, and thalassemia, which are well-described human genetic defects