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Atherothrombosis involves thrombus formation triggered by atherosclerotic plaque disruption and erosion, where tissue factor (TF) expressed in the plaque interacts with factor VII, initiating the coagulation cascade leading to fibrin formation and thrombus development (Yamashita & Asada, 2015

10.2903/j.efsa.2023.7869 6 BerthonJ

Crystallographic data were collected at the Swiss Light Source, beamline X10SA, Paul Scherrer Institute, Villigen, Switzerland SLS

Symptoms of advanced Lyme disease may include: Severe headaches and stiff neck Rash on areas throughout your body Facial palsy (droop) on one or both sides of your face Severe pain and swelling of knees and/or other large joints Pain in bones, joints and soft tissues Irregular heartbeat (Lyme carditis) Dizziness and shortness of breath Brain and spinal cord inflammation Nerve pain Numbness, tingling and shooting pains in the extremities In rare cases, Lyme disease can even cause death

The regulation of dynamic systems that function within the brain, in terms of homeostasis, allostasis and disease states, is delicate