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Ethacrynic acid was the first GST inhibitor shown to possess promising inhibitory activity in vitro, however, its clinical use was limited due to adverse effects and restricted isoenzyme specificity (Tew and Gate 2001)

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Activation of GHRHR signaling in somatotroph cells also induces the release of GH from secretory vesicles as a result of the influx of extracellular Ca 2+

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