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They are naturally produced in the human body and are responsible for a range of functions, such as tissue repair, collagen production, and hormone regulation

To determine a more efficient method for hepatic specification and hepatocyte maturation, and to obtain highly homogeneous functional HLCs, two modified strategies were designed and evaluated (Fig

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Disclosures: Raj Prasad: Nothing to Disclose, Richard Bell: Nothing to Disclose, Nawaz Safdar: Nothing to Disclose, Hauke Lang: Nothing to Disclose, Alfredo Guglielmi: Nothing to Disclose, Thomas van Gulik: Nothing to Disclose, Pim Olthof: Nothing to Disclose, Raj Prasad: Nothing to Disclose 721 A NUCLEOSOME SWITCH PRIMES HEPATITIS B VIRUS INFECTION Nicholas Prescott 1 Andres Mansisidor 2 Yaron Bram 3 Christine Lim 3 Viviana Risca 2 Yael David 4 Robert Schwartz 5 , 1 Memorial Sloan Kettering Cancer Center, 2 Rockefeller University, 3 Weill Cornell Medicine, 4 MSKCC, 5 Weill Cornell Medical College Background: Chronic hepatitis B virus (HBV) infection is a global health problem causing significant liver disease and hepatocellular carcinoma