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on 18 patients with PV (12 males, 6 females) and 18 healthy volunteers found a significant reduction in plasma and RBC GSH-Px and catalase activity and GSH value and increase in plasma MDA level in patients with pemphigus vulgaris.[] ERECTILE DYSFUNCTION The reduced form of glutathione is essential cofactor for NO synthase that catalyzes synthesis of NO from L-arginine in the endothelium

Interestingly, another study using the lung cancer model observed a downregulated expression of 26S proteasome in lung cancer stem cells

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K.BatallerR.Cortez-PintoH.GaoB.GualA.LacknerC.et al (2018)