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The interstitial glucose values were measured at 15 min intervals by the CGM system ( 2.4 Endpoints The primary endpoint was TIR, the percentage of time spent in target range (3.910.0 mmol/L) during the last 2 weeks of treatment (weeks 2224), as recommended from the International CGM Consensus (2019) ( Because the safety profiles of PEG-Loxe and insulin glargine are well characterized, reportable adverse events (AEs) were limited to serious AEs (SAEs), AEs leading to discontinuation of trial drugs, and severe hypoglycemia (requiring assistance from another person)

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Together, these observations indicate a link between mitochondria and diabetes

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