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Intestinal barrier failure, LPS translocation, and disease development

The stability of a protein disulfide bond is determined by its intrinsic stability, K eq , plus the ratio of the concentrations of GSH and GSSG: Only very stable protein disulfide bonds, with large values of K eq , could be populated in the cytosol

Particularly, ferritin phagocytosis promoted by NCOA4, BECN1-mediated system xc inhibition, lysosomal membrane penetration induced by STAT3, and chaperon-mediated autophagy of HSP90 related molecules can all play a role in promoting ferroptosis [135]

doi: 10.59566/IJBS.2008.4089

For vCD44BP immunofluorescent imaging, cells were stained with anti-vCD44BP (clone 7G5, 20 g ml 1 ) for 1 h at 37 C, fixed in 4% PFA for 15 min at room temperature, followed by incubation with biotin-conjugated anti-rat-IgG