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Methods: We co-expressed in mouse hepatocytes mutant NFE2L2 (encoding NRF2) and hMET mutant-CTNNB1 via SB-HDTVi and monitored for HCC development

Also the mechanism of substrate-induced D2 degradation is strongly or completely impaired by replacement of Sec by Cys or Ala, respectively (88), suggesting that modification of this Sec residue during catalysis may be an essential step in the inactivation of the enzyme

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