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Flagellin sensor TLR5 mice / have an altered microbial composition compared to the wild type, manifesting in hyperphagia and metabolic syndrome phenotype ( Aside from the innate immune system, adaptive changes may also have a significant impact on the regulation of the gut microbiota composition ( Microbiome Metabolomics A New Key for Permeability Regulation and Disease Pathogenesis Bacterial metabolic products are in the focus of recent studies, including but not limited to the following: short-chain fatty acid (SCFA) metabolites, tryptophan metabolites (serotonin and tryptamine), bacterial lipopolysaccharides (LPS), and peptidoglycans