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Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers

Experimental blinding: treatment preparation and evaluation of assessment criteria (histological scores, functional measures) must be performed blinded with respect to group assignment

Mechanisms and outcomes Vitamin B12 interventions are commenced upon diagnosis of low B12 status, typically comprise high dose injections until levels are within acceptable range, and then the intervention is changed to a maintenance dose that is typically administered every 3 months ad infinitum

Clinical Endocrinology

Appearance Vitamin Deficiency : Patches tend to be pale (in comparison to the rest of the body) but do contain pigment