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Results showed that LDR (0.090.11 Gy) significantly increased deletion mutants in HPRT in peripheral blood cells, and that the mutation frequency declined with time following exposure

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Conjugation with HMCDs could be a logical approach to increase the tumor specificity and bioavailability in brain tumors, whilst reducing the doses required to overcome liver degradation and minimize toxicity

The high heterogeneity of HNSCC, including differences in HPV status, primary tumor sites, driver gene mutation profiles, and tumor microenvironment heterogeneity, leads to significant inter-individual variations in treatment response, making the traditional one-size-fits-all therapeutic model ineffective