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The disconnect between short plasma half-life and prolonged therapeutic effects observed in many studies supports tissue-level mechanisms extending beyond circulating peptide concentrations

In preclinical models, GIP receptor agonism attenuates emesis while increasing the amount of body weight reduction in comparison to GLP- 1 agonism alone [148]

Because Dihexa initiates synaptic structural changes that take hours to days to fully developrather than producing immediate neurotransmitter effectssplitting the daily dose provides no pharmacodynamic advantage

3.5(b)]

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