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however, this represents early-phase evidence only, and the mechanistic effects observed in trials including increased energy expenditure and lipolysis via glucagon receptor agonism have not yet been fully characterised in long-term human studies

Thus, these data suggest that glycosylation of proIGF-1Ea is required for efficient IGF-1 production and secretion

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Some practitioners recommend starting with a semaglutide-based blend for patients who are GLP-1 naive, since semaglutide has a longer track record and may be easier to titrate