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In most cases, these symptoms are mild to moderate and improve over time, but they can be severe enough for some patients to discontinue treatment (semaglutide STEP 1 trial results)

& Holst, J

This deficiency precludes the formulation of definitive, evidence-based recommendations for their therapeutic use at this time

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Biomarkerguided approaches and targeted delivery (e.g., nanocarrier systems) may minimize offtarget immunosuppression by concentrating therapy in ovarian, adipose, or vascular microenvironments rather than systemic compartments [101]