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Materials and methods 2.1 Bacterial strains and growth conditions The mutagenesis procedure [17], DNA transformation procedures [18], growth conditions [19], and stock preparation of the pneumococcal strains [20] have been previously reported

Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (gluconeogenic genes)

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doi: 10.1016/j.pnpbp.2017.04.012 199 BanatiRHickieIB