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FIGURE 1 Since 2007, Daniel and colleagues (Wjcikowski et al., 2007

GPX7 and GPX8 are cysteine-based with low-catalytic activity and presumed to function in the ER

Differential identification of urine crystals with morphologic characteristics and solubility test

these observations corroborate the notion that specific subtle constraints must exist whereby a particular G6PD variant has a distinctly severe clinical expression but remains compatible with life