glutathione autophagy GPX4 in cell death, autophagy, and disease Ferroptosis regulation in lysosome Lysosomal

Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Frontiers The role of TIGAR in nervous system diseases Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders Neurochemical Research Springer Nature Link Ferroptosis and Its Modulation by Autophagy in Light of the Pathogenesis of Lysosomal Storage Diseases Impaired Glutathione Synthesis in Neurodegeneration

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