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Similar to other regulated forms of necrosis, like necroptosis and pyroptosis, ferroptosis involves the loss of membrane integrity, but the mechanism of loss is different

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2.2 Negative Regulation of Ferroptosis by p53 In addition to its ferroptosis-promoting effects, p53 represses ferroptosis by inducing cyclin-dependent kinase inhibitor (CDKN1A, encoding p21), Parkinson disease 2 (PARK2) and iPLA2, or by inhibiting dipeptidyl peptidase-4 (DPP4) (Kang et al., 2019) (Figure 2)