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Because Gcn4 activity is mainly regulated at the translational level 39 , we next used a high-affinity anti-Gcn4 antibody 40 to monitor Gcn4 protein dynamics

By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release

The peptide was shown to counteract the negative effects of methylprednisolone [9, 10]

Freezing should be avoided as ice crystal formation can damage the peptide structure

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