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In NSCLC, Alimta is approved for various settings, including initial treatment in combination with cisplatin for locally advanced or metastatic non-squamous NSCLC, as maintenance therapy after initial chemotherapy, and as a single agent for patients with locally advanced or metastatic non-squamous NSCLC after prior chemotherapy

For patients receiving B12 replacement therapy for pernicious anaemia or deficiency , monitoring is typically arranged by the prescribing clinician

New mutation of mitochondrial DNAJC19 causing dilated and noncompaction cardiomyopathy, anemia, ataxia, and male genital anomalies