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Antibiotics including rifaximin and metronidazole have been investigated for their capacity to inhibit TMAO formation by targeting gut bacteria that create TMA

The persistent accumulation of ROSarising from endogenous sources (e.g., mitochondrial leakage, enzymatic reactions) and exogenous insults (e.g., ultraviolet radiation, pollutants, tobacco)can overwhelm the antioxidant defense threshold, triggering widespread oxidative damage targeting proteins, lipids, and nucleic acids

Putative intestinal hperammonaemia in horses: 36 cases

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42 , 43 The content of amino acids modified by glycoxidation reactions was expressed in AFU/mg of total protein