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S.Aksu provided the literature update, prepared the figures, and wrote the initial version of the manuscript

Research indicates that Epithalon may help restore rhythmic melatonin levels in aging subjects, thereby supporting sleep-wake cycles and neuroendocrine synchronization

Payet, L

In 1902, scientists Emil Fischer and Franz Hofmeister were the first to propose that proteins are composed of individual amino acids, hypothesizing that bonds are formed between the amino group of one amino acid and the carboxyl group of another, creating the amino acids structure known as a protein peptide

Peptide quantities were unit normalized and hierarchically clustered using the Pearson correlation in Cluster 3.0 (Eisen et al , 1998)