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Together with its oxidized partner (GSSG), GSH maintains cellular redox homeostasis 1 , regulates protein functions through S -glutathionylation 2 , contributes to iron-sulfur cluster maturation 3 , and acts as a signalling molecule to directly activate gene expression 4,5

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Note: It is important to keep in mind that some of the biological activities discussed above were observed in cultured cells and animal models exposed to curcumin at concentrations unlikely to be achieved in cells of humans consuming curcumin orally (see Metabolism and Bioavailability)

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Mischley LK, Leverenz JB, Lau RC, Polissar NL, Neradilek MB, Samii A, et al