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Butterfield and Halliwell, 2019) with dysfunctional glucose metabolism as one earliest manifestation

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Nicotinamide adenine dinucleotide (NADH/NAD + ) and its phosphorylated forms (NADPH/NADP + ) are also important cofactors and core metabolites in the body and are closely related to the synthesis of amino acids, often used as key indicators to evaluate cellular metabolism (Christensen et al., 2017

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