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J Cell Mol Med 24(9):48924899 Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

It acts as a mitochondrial messenger that communicates with the nucleus to maintain cellular homeostasis, making it a promising target for research on metabolic health, exercise performance, and healthy aging 1-4