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In MDSCs, the activation of mGluR2/3 reduces the immunosuppressive properties of MDSCs on T cells and diminishes the effects of MDSCs in cancer cells [176, 177]

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Val-boroPro triggers pyroptosis in primary acute myeloid leukemia (AML) cells by activating the inflammasome sensor protein CARD8 which then activates procaspase-1 (Johnson et al., 2018)

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[771] Additional data demonstrating an improvement in 24-hour and 30-day survival rate among medically evacuated combat casualties in Afghanistan who received prehospital transfusion encouraged research and interest in these techniques for possible deployment by EMS services

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