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doi:10.1016/j.jnutbio.2018.07.011 Tzounis X, Rodriguez-Mateos A, Vulevic J, Gibson GR, Kwik-Uribe C, Spencer JP

Because superoxide cannot cross the membrane of mitochondria, it reacts with water to form hydrogen peroxide, which is very susceptible to spontaneously passing out of the membrane [27]

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Drug-Disease Interactions: Inform your doctor if you have certain medical conditions, such as hypercalcaemia (high calcium levels in the blood), hypercalciuria (high calcium levels in urine), overactive parathyroid glands (hyperparathyroidism), bladder stones, nephrocalcinosis (calcium deposits in the kidney), sarcoidosis (swollen patches of tissue on the skin and lungs), or severe kidney or heart disease, before receiving Calcium-Sandoz Injection

Oral semaglutide barely crosses the blood-brain barrier and the trials enrolled people relatively late in the disease, so a negative treatment result does not settle the prevention question