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coli growth in turbidity assays showed that all the thiol-containing compounds, namely, DTT, GSH, and 2-mercaptoethanol, attenuated the bacteriostatic effect of AX in a concentration-dependent manner ( Figure 6 )

It directly scavenges ROS and reactive nitrogen species (RNS), including superoxide anions, hydroxyl radicals, nitric oxide, and carbon radicals [29,84,87]

Using preclinical models of breast cancer, the team also found they could slow tumor growth by blocking the cancers ability to use glutathione

GSH depletion triggers the lymphocytes apoptotic cascade leading to lymphopenia that affects for the most part T lymphocytes, and lymphopenia is directly associated with severe disease and high mortality rate in COVID-19 patients (Pallard et al., 2009

We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation