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They uncovered a new type of cell death, whereby mitochondria move to the plasma membrane generating ROS, which in turn damages the plasma membrane leading to cell lysis, the type of lysis being termed mitoxyperilysis (Fig

In the context of hereditary disorders related to copper metabolism, mutations in the ATP7A and ATP7B genes result in Menkes disease and Wilsons disease, respectively, both of which are marked by impaired transmembrane transport of copper ions, potentially resulting in copper accumulation across various organs [60, 206]