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The mTOR inhibitor RAD001 potentiates autophagic cell death induced by temozolomide in a glioblastoma cell line

Metabolic rate: GH elevation increases resting metabolic rate through multiple mechanisms, including increased fatty acid oxidation, enhanced thermogenesis, and improved mitochondrial function

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The liver also plays an important role in regulating serum iron levels [18]

These limitations collectively lead to transient and unpredictable therapeutic effects, underscoring the need for mechanistic clarification and technological innovation before mitochondrial transplantation can advance toward clinical application