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The analysis of binding energies showed that compounds with binding energies below 4.25 kcal/mol had possible binding activity, those with energies below 5.0 kcal/mol had stronger binding activity, and compounds with energies below 7.0 kcal/mol had considerable binding activity ( 2.13 Statistical methods Statistical analysis of the data in this study was performed using GraphPad Prism 9.0 software, and the results are expressed as the mean standard error of the mean

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