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-Synuclein has been identified as a major protein component of Lewy bodies and plays a significant role in the pathogenesis of PD [219]

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Under normal circumstances, melanin distributes evenly throughout the skin, providing natural coloration and protection

Indeed, this system accounts for approximately 20% of abluminal Na-dependent Gln transport activity, whereas system N mediates the majority of Gln transport across the abluminal membrane ( Transport of Large and Small Neutral AAs: System ASC This is a Na + -dependent system located exclusively on the luminal membranes of the BBB, whose name ASC was derived from the three main substrates Ala, Ser, and Cys, although Gly and several essential AAs are also putative substrates, including Met, Val, Leu, Iso, and Thr (Tayarani et al., 1987)