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This is because anemia (B12 deficiency) is caused by a lack of enough oxygen carried throughout your body, making you feel weak and tired

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In this matter, neuronal death is thought to be a consequence of the inhibition of mitochondrial complex I, which leads to a reduction in the energy supply and subsequent collapse of the mitochondrial membrane potential [66]

Machine learning models integrating these metabolites with gut microbiota profiles (e.g., Gemmiger abundance, SCFA-producer/proteolytic bacteria ratios) demonstrate superior DKD risk stratification compared to traditional markers alone (AUC 0.830.93) (136, 138, 152)

Thiamine and Magnesium Deficiencies: Keys to Disease