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1 ppb PID Cairns et al

GS, differently from GCL, is not feedback-inhibited by GSH and it is not associated with a regulatory subunit

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Moreover, our biochemical and genetic analysis, including the generation of Il1b K133R/K133R mice, highlight that IL-1 K133 ubiquitylation limits IL-1 levels and therefore Caspase-1-mediated activation both in vitro and in vivo