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Measurement of antioxidant levels is considered a potential tool for the early diagnosis and monitoring of disease progression in MASLD [158]

The accumulation of lipid peroxides in cell membranes destroys membrane integrity and cellular functions, ultimately leading to ferroptosis

Adult Sox2 + stem cell exhaustion in mice results in cellular senescence and premature aging

However, the identity of the catalytic factor(s) besides pyridoxine(phosphate) in the media and tissues that gives rise to non-enzymatic H 2 S production is yet to be identified

Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, OLeary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR, IRIS Trial Investigators