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Sometimes opioid overdose can include pulmonary edema (fluid leak into the airspaces of the lung) this manifests as foam coming out of your mouth

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People with a compromised immune system If you have a weakened immune system whether its because of chemotherapy, organ transplantation, biologics or HIV you face a double challenge: Not only are you more vulnerable to severe illness if you get the flu, but your immune response to the vaccine may be blunted