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In parallel, translational studies must determine whether exerkine-targeted therapies or exercise mimetics can safely and reproducibly recapitulate the retinal benefits of physical activity, while accounting for inter-individual variability driven by age, disease stage, and metabolic status that may influence exerkine responsiveness and therapeutic feasibility

Figure 7.4 Basic structure of nucleotides

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J Gen Physiol 94:911935 Dhar-Chowdhury P, Harrell MD, Han SY, Jankowska D, Parachuru L, Morrissey A, Srivastava S, Liu W, Malester B, Yoshida H (2005) The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the KATP channel macromolecular complex and regulate its function