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A regioselective nitration of 14 may be used to selectively install a nitro group at the C3 position of compound 14 or the like, followed by chlorination of the quinoline-N-oxide moiety in the presence of POCl 3 to give intermediate 15

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Various secondary alkyl halides are then readily attacked by the modified B 12s to give the corresponding stable cobalamin analogs

For instance, non-biodegradable fillers, such as polymethylmethacrylate (PMMA) or silicone, are more likely to cause long-term complications compared to biodegradable fillers like hyaluronic acid