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Furthermore, standard extrapolation of the fomepizole dose that prevents JNK activation in mice to humans would suggest a human equivalent dose of about 4 mg/kg, more than 3 times lower than the standard 15 mg/kg loading dose used clinically

Treatments provided were twice weekly hyperbaric ozone sessions of 4 passes of 200 ml blood with 200 cc ozone gas at 70 mcg/cc at nearly 2 ATA pressure in a glass bottle