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2021;9(9):e3803

Because triamterene is a weak folic acid antagonist, megaloblastic anemia has been reported in patients with decreased folic acid stores

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Indeed, as current in vitro and in vivo toxicity testing methods are mainly used to evaluate the acute and subacute toxicity of metal-based NPs, nanotoxicity testing methods for chronic long-term NPs exposure, which are crucial for predicting chronic toxicity in humans, are still lacking

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