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When patients present with concurrent HPG axis dysfunction, the use of SERMs (e.g., Clomiphene) or aromatase inhibitors (e.g., Anastrozole) can elevate serum testosterone and potentially improve semen parameters

Genetic and Metabolic Targeting: The development of cell-specific ferroptosis loss-of-function models (e.g., epithelial- or immune-specific GPX4 or ACSL4 knockout systems) will enable precise dissection of compartment-specific contributions to inflammation and metabolic dysregulation

Oncotarget 9 , 3036330384 (2018)

Statements Author contributions AM: Investigation, Supervision, Software, Writing original draft, Project administration, Validation, Resources, Formal Analysis, Conceptualization, Visualization, Methodology, Data curation

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