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FIGURE 3 Protection Against AQ-QI- and DEAQ-QI-Induced Apoptosis by GSTP1 To test whether AQ-QI and DEAQ-QI exposure induced apoptosis and to study the protective potential of GSTP1, activity of caspase 3 was measured under normal and GSH-depleted conditions ( Figure 4 )

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In mammals, ATAC contains one of the two highly related, mutually exclusive catalytic subunits, GCN5 or PCAF, which are shared with another major HAT complex, the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex 13,14

The naturally occurring substitution of the methionine at position 105 by isoleucine (M105I) in -SNAP, known as the hyh (hydrocephalus with hop gait) mutation, provokes a neurodevelopmental phenotype characterized by fetal-onset hydrocephalus, abnormal corticogenesis, agenesia of the corpus callosum, periventricular heterotopia, and cerebellar hypoplasia, among other pathological features 13,14,15,16,17,18