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Metal chaperones such as CQ and PBT2, which maintain metal ion homeostasis, have been shown to restore cognition, elevate zinc levels in the hippocampus, and restore levels of key proteins involved in learning/memory and synaptic plasticity in ZnT3 knockout mice

These synergistic interventions constitute critical determinants in preventing age-related immunosenescence and mitigating the pathogenesis of various inflammation-associated disorders, including metabolic syndrome, cardiovascular diseases, and neurodegenerative conditions (Fig

Karabiyik C, Frake RA, Park SJ, Pavel M, Rubinsztein DC

Current neuropharmacology, 12(2), 140147