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The first intervention class targets hepatic fat accumulation by modulating PPARs (i.e., pemafibrate and elafibranor), targeting FXR signaling (i.e., obeticholic acid and celastrol), inhibiting de novo lipogenesis (i.e., aramchol and ACC inhibitors), and utilizing fibroblast growth factor analogues [347]

of NaI was added to accelerate the alkylation reaction

To confirm the contribution of zonulin to early permeability changes in celiac disease, 20 patients on a gluten-free diet were randomized to a 3-day larazotide (12 mg once daily) or placebo treatment with a 2.5 g oral gluten challenge on the second day (96)

doi: 10.1016/j.jad.2024.02.069 54 LiX

Matrix metalloproteinases (MMPs) are a family of over 20 different endopeptidases that each degrades several extracellular matrix proteins and non-matrix substrates