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23 In the situation of a vertebral fracture (injury type A2) but intact disc/endplate complex and in the presence of sufficient bone quality, the involved trauma energy can by assumed to be much higher than in the aforementioned twin study from Hancock and Batti

FIGURE 1 3.1.1.3 Cancer metastasis and ROS Excessive level of ROS leads to metastasis via the stimulation of mitogen-activated protein kinase (MAPK), and phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI2K/Akt/mTOR) signaling pathways that directs the activation of downstream metalloproteinase 9 (MMP9), metalloproteinase 2 (MMP2), SNAIL enzymes which initiate epithelial-mesenchymal transition (EMT) to metastasis (Deepika et al., 2013)

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